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KMID : 0380020170320030187
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Korean Journal of Biotechnology and Bioengineering
2017 Volume.32 No. 3 p.187 ~ p.192
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Effects of Rumex axetosella, Sonchus oleraceus and Euphoibia jolkini Extracts on Melanin Synthesis in Melanoma Cells
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Kim Min-Jin
Kim Seo-Yeon
Hyun Kwang-Hee
Kim Duk-Soo
Kim Seung-Young
Hyun Chang-Gu
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Abstract
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In this study, we investigated the effect of Rumex axetosella, Sonchus oleraceus and Euphoibia jolkini extracts on tyrosinase activity and melanin production as natural products of whitening functional cosmetics. To measure the melanin production, 50, 100, 200 μg/mL of Rumex axetosella, Sonchus oleraceus and Euphoibia jolkini extracts were treated on α-MSH treated B16F10 melanoma cells, respectively. Melanin contents in α-MSH treated B16F10 melanoma cells were decreased by 41.5, 51.11, and 61% in 200 μg/mL treatment compared to none treatment, respectively. In addition, the intracellular tyrosinase activity was decreased after treatments with all extracts. Furthermore, 100 μg/mL of Euphoibia jolkini extract was decreased 81.5% of melanin production in B16F10 melanoma cells. When the three extracts were compared, Euphoibia jolkini extract was considered to be the most functional material for whitening effect.
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KEYWORD
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Rumex axetosella, Sonchus oleraceus, Euphoibia jolkini, Melanin, Tyrosinase
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